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Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid synthesized from codeine, one of the opioid alkaloids found in the opium poppy. It is a narcotic analgesic used orally for the relief of moderate to severe pain. In one study comparing the potency of hydrocodone to that of oxycodone, it was found that it took 50% more hydrocodone to achieve the same degree of miosis. The investigators interpreted this to mean that oxycodone is about 50% more potent than hydrocodone. Equal amount of either drug provided about the same degree of pain relief, indicating that there is little practical difference between them when used for that purpose. the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours. Recommended dosing interval is 4–6 hours.
Hydrocodone is used to treat moderate to severe pain and as an antitussive to treat cough.
Most common side effects of Hydrocodone are lightheadedness, dizziness, euphoria, sedation, nausea, and vomiting. Less common effects include drowsiness, confusion, lethargy, anxiety, fear, unease, psychic dependence, mood changes, impairment of mental and physical performance, constipation, inability to urinate, bladder spasms, inadequate breaths, hearing impairment, permanent hearing loss, rash, and itching. If any of these less common side effects are observed, please contact your doctor. Symptoms of hydrocodone overdose include narrowed or widened pupils; slow, shallow, or stopped breathing; slowed or stopped heartbeat; cold, clammy, or blue skin; excessive sleepiness; loss of consciousness; seizures; or death.
Hydrocodone can be habit-forming, causing physical and psychological dependence. Its abuse liability is similar to morphine and less than oxycodone.
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